Metronidazole- and Amoxicillin-Loaded PLGA and PCL Nanofibers as Potential Drug Delivery Systems for the Treatment of Periodontitis: In Vitro and In Vivo Evaluations

The purpose of this study was to prepare poly (D-L) lactide-co-glycolide (PLGA) and ?-caprolactone (PCL) nanofibers containing metronidazole amoxicillin using an electrospinning process as intrapocket sustained-release drug delivery systems for the treatment periodontal diseases. Scanning electron microscopy showed that PLGA PCL produced from uniform bead-free in morphology. obtained had a strong structure resisted external tension according tensiometry results. cytotoxicity results indicated acceptable cell viability (>80%). Quantification by high-performance liquid chromatography almost complete vitro release between 7 9 days, whereas 14 days were required vivo. No significant signs irritation or inflammatory reaction detected after three weeks subcutaneous implantation animal models, thus indicating suitable compatibility. therefore suggest designed can be used potential commercial formulations periodontitis controlled-release increase patient compliance. This is due their ability reduce frequency administration times daily systemic manner once weekly local delivery.